Modeling and simulations of cardiovascular flows. Application to an image-based patient-specific clinical study

In recent years, image-based patient-specific computational hemodynamics became a valuable non-invasive complementary tool for understanding the progression of vascular diseases, giving additional insight in terms of flow patterns, pressure, wall shear stress, as well as by computing clinically relevant indicators.

In this lecture we address the geometric multiscale approach for the numerical simulation of blood flow problems, meaning that the whole circulatory system is represented by mathematical models of different geometric dimensions, interacting through appropriate interface conditions. Specific numerical techniques are required to couple 3D fluid-structure interaction models used in the region of interest with reduced 1D and 0D models.

Our contribution to the development of CFD methods to study the formation and evolution of intracranial aneurysms using anatomically realistic geometries obtained from rotational CTA, will also be presented.