Caroline Bazzoli
Maître de Conférences / Assistant Professor (Université Pierre Mendès France)
Docteur en Mathématiques Appliquées / PhD in Applied Mathematics
Spécialité Biostatistique / Speciality Biostatistics
Member of SAM team
| Address: | Laboratoire Jean Kuntzmann 51 rue des Mathématiques, BP 53 38041 Grenoble cedex 9 France |
| Bureau : | 32 (3ème étage) |
| Phone: | +33 (0)4 76 51 45 47 |
| Fax: | +33 (0)4 76 63 12 63 |
| E-mail: | caroline (.) bazzoli (at) imag (.) fr |
Research
Research topics
Design optimisation in nonlinear mixed-effect models
Modelling of population PK/PD experimental data
Pharmacology of antiretroviral drugs in HIV patients
Publications
Articles:
• Guedj J, Bazzoli C, Neumann AU, Mentré F. Design evaluation and optimization for models of hepatitis C viral dynamics. Stat Med. May 10;30(10):1045-56.
• Bazzoli C, Bénech H, Rey E, Retout S, Salmon D, Duval X, Tréluyer JM, Mentré F; the COPHAR2-ANRS 111 Study Group. Joint Population Pharmacokinetic Analysis of Zidovudine, Lamivudine, and Their Active Intracellular Metabolites in HIV Patients. Antimicrob Agents Chemother. Jul;55(7):3423-3431.
• Bouillon-Pichault M, Jullien V, Bazzoli C, Pons G, Tod M. Pharmacokinetic design optimization in children and estimation of maturation parameters: example of cytochrome P450 3A4. J Pharmacokinet Pharmacodyn. Feb;38(1):25-40.
• Bazzoli C, Jullien V, Le Tiec C, Rey E, Mentré F, Taburet AM. Intracellular Pharmacokinetics of Antiretroviral Drugs in HIV-Infected Patients, and their Correlation with Drug Action. Clin Pharmacokinet. 49(1):17-45.
• Bazzoli C, Retout S, Mentré F. Design evaluation and optimisation in multiple response nonlinear mixed effect models: PFIM 3.0. Comput Methods Programs Biomed. Apr;98(1):55-65.
• Bazzoli C, Retout S, Mentré F. Fisher information matrix for nonlinear mixed effects multiple response models: evaluation of the appropriateness of the first order linearization using a pharmacokinetic/pharmacodynamic model. Stat Med. Jun 30;28(14):1940-56.
• Bazzoli C, Retout S, Mentré F. Design optimisation in nonlinear mixed effects models using cost functions:application to a joint model of infliximab and methotrexate pharmacokinetics. Commun Stat-Theory Methods. 38 : 3351-68.
Conference proceedings:
Software development
PFIM :
R functions for design evaluation and optimisation for nonlinear mixed effects models and dedicated to the scientific community and the pharmaceutical industry. Functions are based on the development of the Fisher Information matrix
in this context. (wwww.pfim.biostat.fr)
Enseignement
Matières enseignées au département STID (Statistique et Informatique décisionnelle) :
1ère Année
70h Statistiques descriptives (Cours/TP)
Encadrement de projets tuteurés
28h Introduction á la Statistique Inférentielle
2ème Année
18h Analyse de la Variance
16h Data Mining (Classification, Arbre de decision, Analyse discriminante)
LP ESSM
10h Mise á Niveau de Statistique Descriptive
20h Analyse de Données (Analyse en Composantes Principales, Analyse Factorielle des Correspondances, Analyse des Correspondances Multiples)
Encadrement de projets tuteurés